Pathophysiology of Hepatorenal Syndrome - Dilation of splanchnic arteries initially compensated by increased CO eventually decompensates with activation of mechanisms to preserve ECBV (RAAS, SNS, ADH) leading to fluid retention (ascites, edema) and renal failure due to intrarenal vasoconstriction.Bacterial translocation and the resulting inflammatory response may contribute to splanchnic vasodilation (through production of vasoactive factors like NO). #Pathophys #Nephro #IM #HepatorenalSyndrome #Hepatorenal #Syndrome #HRS #Ddxof