Primary Biliary Cirrhosis - Pathophysiology
Environmental ...
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Description

Primary Biliary Cirrhosis - Pathophysiology

Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish

Epigentics Risk Factors: miRNA profiles, Oestrogen (female-predominant disease), DNA methylation

Genetic Risk Factors: HLA variants, Non-HLA variants (immunoregulatory gene loci), Personal/family history of autoimmune disease, First-degree relative with PBC

Pathophysiology:

 - Coordinated T & B cell mediated autoimmune cascade with T-cell mediated BEC injury

 - Loss of the protective bicarbonate-rich umbrella around BECs and gradual loss of bile ducts

 - Progressive inflammation and biliary fibrosis

 - Cholestasis



#PBC #Primary #Biliary #Cirrhosis #Pathophysiology #hepatology
Contributed by

Dr. Michael Chew
@mchew85
GrepMed Gastroenterology-Hepatology Editor, Academic Hospitalist UC Davis Medical Center Internal Medicine, Yale Gastroenterology Fellow '22
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