Cephalosporin Coverage

First-generation cephalosporins: 

 - Gram (+) cocci: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, Anaerobic streptococci

 - Gram (-) rods: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis

Second-generation cephalosporins:

 - Gram (+) cocci: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, 

 - Anaerobic streptococci

 - Gram (-) cocci: Neisseria gonorrhoeae

 - Gram (-) rods: Enterobacter aerogenes, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Proteus mirabilis

 - Anaerobic organisms* *

Third-generation cephalosporins:

Gram (+) cocci: Streptococcus pneumoniae, Streptococcus pyogenes, Anaerobic streptococci

 - Gram (-) cocci, Neisseria gonorrhoeae

 - Gram (-) rods: Enterobacter aerogenes, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens



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