Cold Urticaria
Prevalence - 0.05% in the population
Disease ...

Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes and clinical associations - 1. Infections 2. Autoimmune diseases 3. Lymphoproliferative diseases 4. Drugs 5. Foods 6. Insect stings
Disease trigger - Direct skin contact with cold air, objects, liquids 
The onset and duration of symptoms - 1-5 minutes after the cold exposure, resolve within one hour or longer.
Predisposition - Female predominance
Anaphylaxis - 5-50% of patients
Skin lesions - Wheals/angioedema

Other symptoms - Headache, fever, fatigue, Nausea, abdominal pain, diarrhea, Tachycardia, shortness of breath, Hypotension, shock, Uterine contractions, Disorientation, vertigo
Diagnostic tests - Ice cube test, TempTest test 
Cryoglobulins/cryofibrinogen - < 1% of patients
Skin histology - Mast cell degranulation, perivascular cellular infiltration (lymphocytes, neutrophils and eosinophils)
Comorbidity - Atopic diseases, Chronic spontaneous urticaria, Chronic inducible urticarias

doi: 10.1111/all.14674

#Cold #Urticaria #diagnosis #rheumatology #comparison #table
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