Effects of prophylactic anticholinergic medications to decrease extrapyramidal side effects in patients taking acute antiemetic drugs: a systematic review and meta-analysis. Source: https://www.ncbi.nlm.nih.gov/pubmed/29431143



One-Liner: Diphenhydramine reduces extrapyramidal side effects (EPS) when antidopaminergics (metoclopramide and prochlorperazine) are given rapidly (over 2 min bolus) but offers no benefit over placebo when given slowly (over 15 min infusion); the fewest overall EPS are seen when antiemetic given as a 15 min infusion (with or without diphenhydramine).



Visual Abstract by David Cisewski, MD https://twitter.com/dhcisewski



#Benadryl #Prophylactic #Anticholinergics #Extrapyramidal #EPS #Antiemetics #VisualAbstract #EBM