Macroglossia in Light-Chain Amyloidosis- Physical examination revealed macroglossia, with indentations from the teeth (Panel A)...A biopsy of the tongue was performed, and the findings confirmed a diagnosis of light-chain (AL) amyloidosis, which appears under polarized microscopy as an apple-green birefringence after Congo red staining (Panel B). Lambda chains were revealed on immunohistochemical analysis (not shown). In primary systemic, or AL, amyloidosis, monoclonal light chains are deposited in tissues. AL amyloidosis is a well-recognized cause of macroglossia. Early diagnosis and treatment are critical to prevent irreversible organ damage. #macroglossia #amyloidosis #clinical #photo #AL #lightchain #NEJM