Adult Vancomycin Guidelines
The information below provides general dosing guidelines for vancomycin. A maintenance regimen of 15-20 mg/kg/dose with the frequency determined by current creatinine clearance is the accepted dosing method. There is no clinical utility of peak serum concentrations, and therefore these should not be routinely measured. Serum trough concentrations should be routinely measured and serve as a surrogate indicator of the AUC: MIC ratio.1 Dosing in renal impairment requires changes in dosing and monitoring methods and often requires a detailed reference source and nephrology consultation. Although vancomycin has been associated with nephrotoxicity and acute kidney injury, causality has not been confirmed, especially in complex critically ill patients.


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