Folic acid is a synthetic member of the folate (Vitamin B9) family, a group of chemically related compounds with shared biological activity. Naturally occurring folates exist primarily in reduced, methylated and/or polyglutamate-conjugated states and have relatively low oral bioavailability. Folic acid is oxidation-resistant and demonstrates increased bioavailability and stability. Dietary folates and orally administered folic acid are absorbed intestinally, reduced to dihydrofolate and tetrahydrofolate (THF) by dihydrofolate reductase (DHFR), and released into circulation.


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