Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions on the skull, which had an appearance known as “raindrop skull” — a pattern of lytic or punched-out lesions that resemble raindrops hitting a surface and splashing. These findings are characteristic of multiple myeloma. The diagnosis was confirmed by bone marrow biopsy and aspirate samples that showed 50% clonal plasma cells in the marrow; serum protein electrophoresis revealed a monoclonal IgA paraprotein... #NEJM #clinical #radiology #skull #raindrop #multiple #myeloma