Systemic Inflammatory Response Syndrome (SIRS) Criteria - Definitions of Sepsis, Severe Sepsis and Septic Shock



Systemic Inflammatory Response Syndrome (SIRS) 

Two or more of the following criteria: 

1 Heart rate > 90 

2 Temp > 100.40F (380C) or < 96.80F (360C) 

3 Respiratory rate > 20 or PaC02 < 32 mm Hg 

4 WBC > 12,000/mm3 or < 4,000/mm3, or > 1096 band forms 



Sepsis = SIRS + Suspected or present source of infection 

Severe Sepsis = Sepsis + Lactic Acidosis or SBP < 90 or SBP drop > 40 (Organ dysfunction, Hypotension, or hypoperfusion) 

Septic Shock = Severe Sepsis + Hypotension, despite adequate fluid resuscitation 



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