Antifungal Azoles - Antibiotics Class Overview


Mechanism:  inhibit ergosterol synthesis (important component of fungal cell membranes)
 - Main metabolism is hepatic, main toxicity is elevated LFTs.
 - Only Fluconazole has adequate urinary penetration.  Itraconazole has poor CNS penetration compared to the others. 
1. Fluconazole(PO or IV)
2. Itraconazole(PO or IV)
3. Voriconazole(PO or IV)
4. Posaconazole(PO only)
5. Isavuconazole(PO or IV)


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