Antifungal Polyenes - Amphoterecin B, Abelcet, Ambisome - Antibiotics Class Overview


Mechanism: binds ergosterol in membrane and forms membrane pores à fungicidal.
Drug of choice for many severe fungal infections: Zygomycetes, Cryptococcal Meningitis (induction phase with flucytosine), Severe Histoplasmosis/Blastomycosis/Coccidioidomycosis
2nd-line for invasive aspergillosis (voriconazole is drug of choice).  2nd-line for candida infections – because echinocandins are at least as effective, and less toxic.


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