Flutycosine - Antibiotics Class Overview
Mechanism: 5-FC interferes with DNA and protein synthesis. Only available PO in the US
- Used in combination with Amphoterecin B for initial management of several severe fungal infections: Severe cryptococcal pneumonia and meningitis, severe candidal infections (endocarditis, meningitis)
- Virtually never used as monotherapy due to high incidence of primary and acquired resistance (monotherapy reserved for non-severe candida urinary tract infections)
- Main adverse effects = Hematologic (Leukopenia and Thrombocytopenia) and Hepatic toxicity.
- Drug levels should be monitored to reduce toxicity.
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