Flutycosine - Antibiotics Class Overview
Mechanism: ...

Flutycosine - Antibiotics Class Overview

Mechanism: 5-FC interferes with DNA and protein synthesis.  Only available PO in the US
 - Used in combination with Amphoterecin B for initial management of several severe fungal infections: Severe cryptococcal pneumonia and meningitis, severe candidal infections (endocarditis, meningitis)

 - Virtually never used as monotherapy due to high incidence of primary and acquired resistance (monotherapy reserved for non-severe candida urinary tract infections)
 - Main adverse effects = Hematologic (Leukopenia and Thrombocytopenia) and Hepatic toxicity.  
 - Drug levels should be monitored to reduce toxicity.

#Pharmacology #Antibiotics #Review #Overview #Flutycosine #Antifungal
Contributed by

Dr. Gerald Diaz
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG:  https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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