SPICE (SPACE) Organisms

 - Colloquial acronym for gram-negative bacteria that have inducible, chromosomal beta-lactamase genes known as AmpC.

 - Resistance may not be detectable initially, but appears after a period of exposure to beta-lactam antibiotics

 - Organisms in this group include: 

    • Serratia

    • Providencia

    • "Indole-positive" Proteus species / Acinetobacter

    • Citrobacter

    • Enterobacter species

 - Other organisms in this class include: Acinetobacter, Cronobacter, Edwardsiella, Hafnia, Morganella, and rarely Pseudomonas



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