Manifestations of Anaphylaxis by Body System


Dermatologic/mucosal

 - Eyes: periorbital swelling/erythema, injected conjunctiva, tears

 - Oral mucosa: angioedema of the tongue and lips

 - Skin: urticarial rash, pruritus or flushing, morbilliform rash, piloerection, angioedema


Respiratory

 - Lower airway: bronchospasm with wheezing or cough, chest tightness, tachypnea, decreased peak expiratory flow, cyanosis, respiratory collapse/arrest

 - Upper airway: sensation of throat constriction; dry cough; difficulty breathing, swallowing, speaking; changes in voice; stridor; cyanosis; respiratory collapse/arrest


Cardiovascular

 - Early: tachycardia, diaphoresis, delayed capillary refill, hypotension

 - Late: bradycardia, shock, T-wave inversion and ST depression in multiple leads, cyanosis, cardiac arrest


Gastrointestinal

 - Nausea, vomiting, diarrhea, abdominal cramps

Neurologic

 - Throbbing headache, dizziness, lightheadedness, confusion, tunnel vision, loss of consciousness

General

 - Anxiety, feeling of impending doom, metallic taste, paresthesia in extremities, malaise, weakness

In children: sudden behavior changes, irritability, cessation of play

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