Glomerular Diseases - Nephritic and Nephrotic Syndromes


Nephritic syndrome—due to GBM disruption. 

Hypertension. t BUN and creatinine. oliguria. 

hematuria. RBC casts in urine. Proteinuria often 

in the subnephrotic range (< 3.5 g/day) but in 

severe cases may be in nephrotic range. 


Nephrotic yndrome—podocyte disruption 

—+ charge barrier impaired. Massive proteinuria 

(> 3.5 g/day) with hypoalbuminemia. 

hyperlipidemia edema. May be 10 (eg direct 

podocyte damage) or 20 (podocyte damage 

from systemic process leg. diabetes)) 

#Glomerular #Diseases #Nephritic #Nephrotic #Syndromes #Classification #Proteinuria #Nephrology #Diagnosis