Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine. oliguria. 
hematuria. RBC casts in urine. Proteinuria often 
in the subnephrotic range (< 3.5 g/day) but in 
severe cases may be in nephrotic range. 

Nephrotic yndrome—podocyte disruption 
—+ charge barrier impaired. Massive proteinuria 
(> 3.5 g/day) with hypoalbuminemia. 
hyperlipidemia edema. May be 10 (eg direct 
podocyte damage) or 20 (podocyte damage 
from systemic process leg. diabetes)) 

#Glomerular #Diseases #Nephritic #Nephrotic #Syndromes #Classification #Proteinuria #Nephrology #Diagnosis