Diffuse Sclerosis Variant—PTC 
 - Rare variant of PTC 
 - Approximately 3% ofall PTC 

 - Common in children and young adults 

 - May present as bilateral goiter 

 - Ultrasound shows multiple calcifications 

(can be mistaken for chronic 

lymphocytic thyroiditis) 

 - Cytology:  
 • 

Carcinoma cells arranged in nests 
 • 

Numerous psammoma bodies 
 • 

Foci of non-psammomatous 

calcifications 
 • 

Brisk lymphocytic infiltrate 

around the tumor cells 
 • 

Squamoid change in tumor nests 
 • 

Variable molecular profile- 

RET/PTC rearrangements 

(RET/PTCI > RET/PTC 3) & BRAF 

V600e mutations. RET/PTC3 in 

patients with advanced disease. 
 • 

KIF5B/RET rearrangement is 

reported in a fatal tumor 


 - Dr. Zubair Baloch

@aakasharmand


#Diffuse #Sclerosis #Variant #PTC #Papillary #Thyroid #Cancer #Pathology #Clinical #Gross #Microscopy