Naloxone Dosing Algorithm

Empirical trials are needed to determine the effective dose of naloxone. Patients who do not have a response to an initial dose of naloxone should receive escalating doses until respiratory effort is restored. Naloxone, which is frequently dispensed as an injectable solution in doses of 0.4 mg per milliliter and 1 mg per milliliter for adults, is almost devoid of adverse effects. Pediatric patients are defined as children up to the age of about 5 years or with a body weight of up to 20 kg. Pediatric patients with opioid intoxication frequently require larger doses of naloxone to reverse the effects of overdose because of the relatively higher ingested dose per kilogram of body weight.

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