Oxyhemoglobin Dissociation Curve 



Left Shift - decreased unloading of O2 at tissue level (i.e.  increased affinity) 

 - decr H+ (alkalosis) 

 - decr temperature 

 - 2 , 3 -diphosphoglycerate: 

      • stored red blood cells 

 - Hb variant 

     • fetal hæmoglobin 

     • methæmoglobin 

     • carboxyhæmoglobin 

 - Carbon monoxide poisoning 

 - Hypophosphatæmia 



Right Shift - increased unloading of O2 at tissue level (i.e. decreased affinity) 

 - incr H+ (acidosis) 

 - incr temperature

 - incr 2,3-diphosphoglycerate: 

      • pregnancy 

      • chronic anæmia 

      • arterial hypoxemia 

 - Sickle cell anemia 



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