Causes of False Elevation and Reduction in HbA1c



== False Elevation ==

Decreased RBC turnover 

• Iron, B-12, or folate deficiency 

• Asplenia 

Laboratory Interference 

• Hyperbilirubinemia 

• Hypertriglyceridemia 

• Uremia 

High Glucose Content 

• RBC Transfusions 



== False Reduction ==

Increase RBC turnover 

• Acute blood loss 

• Hemolytic anemia 

• Splenomegaly, Sickle Cell 

• End-stage renal disease 

Inhibition of glycosylation 

• Vitamin C & E 

Dilutional Effect 

• RBC Transfusions 



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