Adverse Effects of NSAIDs

Prostaglandins decreased

 - Gastric mucosal damage with ulcer formation, bleeding, and perforation

 - Nephropathy, decreased excretion of NaCl and H2O, edemas, increased blood pressure, impaired wound healing, diarrhea, disturbed uterine motility

Leukotrienes increased

 - Bronchoconstriction, bronchial asthma, proinflammatory effect



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