Therapy for Benign Prostatic Hyperplasia (BPH) 
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Therapy for Benign Prostatic Hyperplasia (BPH) 

5 Alpha-Reductase inhibitors

 • Flnasterlde and dutasterlde act by reducing the size of the prostate gland. Treatment for 6 to 12 months is generally needed before prostate size is sufficiently reduced to improve symptoms.

 • The major side effects of the 5 a-reductase inhibitors are decreased libido and ejaculatory or erectile dysfunction.

Alpha-1-Adrenergic Antagonists

 • Terazosin, doxazosln, tamsulosln, silodosin, and alfuzosin relieve outlet obstruction of the bladder by reducing the tension of prostatic smooth muscle In the prostate, prostate capsule, and bladder neck.

 • The most important side effects are orthostatic hypotension and dizziness.

Combination therapy

• Combination therapy with an alpha1-adrenergic antagonist plus a 5 alpha reductase inhibitor produces the greatest reduction in the symptoms of BPH, such as acute urinary retention, urinary Incontinence, renal insufficiency, or recurrent urinary tract infections.



#Benign #Prostatic #Hyperplasia #BPH #Prostate #Medications #Pharmacology
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