Primary Bone Tumors - Differential Diagnosis Algorithm 



Metastatic - Most common tumour in adults

 - Breast

 - Prostate

 - Thyroid

 - Lung

 - Renal

Primary

Benign

 • Osteochondroma

 • Osteoid osteoma

 • Chondroblastoma

 • Friboxanthoma

 • Fibrous Dysplasia

 • Non-ossifying fibroma

 • Chondromyxoid Fibroma

 • Periosteal Chondroma

Aggressive, Non-Malignant

 • Giant Cell Tumour

 • Enchondroma

 • Aneurysmal Bone Cyst

Malignant - 66% of adult tumours

 • Multiple Myeloma- most common

 • Osteosarcoma

 • Chondrosarcoma

 • Ewing's Sarcoma

 • Fibrosarcoma

 • Liposarcoma

 • Rhabdomyosarcoma

 • Leiomyosarcoma

 • Malignant Fibrous Histiocytoma



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