Erectile Dysfunction: Pathogenesis

Erectile Dysfunction ...
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Description

Erectile Dysfunction: Pathogenesis



Erectile Dysfunction - Persistent or recurrent inability to achieve an erection sufficient to achieve desired sexual performance



Psychogenic Erectile Dysfunction

Sudden onset, sporadic -> (circumstantial), younger, nocturnal/AM erection present -> Anxiety, depression, strained relationship, lack of sexual arousal, psychological disorder -> Possible mechanisms include an imbalance of central neurotransmitters, over inhibition of spinal center by the brain, and sympathetic overactivity

 -> Normal Noctumal penile tumescence and rigidity



Neurogenic Erectile Dysfunction

Neurologic disease, trauma, iatrogenic, diabetes mellitus -> Central (cerebral or spinal cord); peripheral (afferent/sensory neuropathy) or efferent (autonomic neuropathy) -> decreased parasympathetic nerve firing -> decreased NO release

 -> Abnormal Nocturnal penile tumescence and rigidity



Endocrinologic Erectile Dysfunction

Hypogonadism, hyperprolactinemia, hyperthyroidism, alcoholism, iatrogenic

 -> circulating free testosterone



Vasculogenic Erectile Dysfunction

Hypertension, smoking, hyperlipidemia, diabetes, cardiovascular disease, iatrogenic

 -> Endothelia cell damage and small vessel disease (penile artery diameter 1-2 mm)



#Erectile #Dysfunction #Pathophysiology #Urology #Diagnosis
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The Calgary Guide to Understanding Disease
@TheCalgaryGuide
Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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