Dupuytren’s Disease: Pathogenesis and Clinical Findings
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Description

Dupuytren’s Disease: Pathogenesis and Clinical Findings

 • Aging, smoking and/or diabetes -> Microangiopathy and palmar fascia ischemia releasing free radicals

 • Alcoholism -> Incr conversion of xanthine dehydrogenase to xanthine oxidase releasing free radicals

 • Trauma -> Generation of IL-1 and/or ischemia of palmar fascia

 • North European descent -> Autosomal dominant with variable penetrance

 • Males -> Expression of androgen receptors in fascia

=> Overproliferation of fibroblasts and type III collagen deposition in palmar/digital fascia

=> Dupuytren's: benign fibromatosis of palmar and digital fascia



#Dupuytrens #Disease #Contractures #pathophysiology #msk
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The Calgary Guide to Understanding Disease
@TheCalgaryGuide
Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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