Hyperthyroidism - Differential Diagnosis Algorithm

High/Normal Radioiodine Uptake

 - Autoimmune Thyroid Disease:

    • Grave's Disease

    • Positive anti-TSH Receptor Antibody

 - Autonomous Thyroid Tissue:

    • Toxic Adenoma

    • Toxic Multinodular Goiter

 - TSH/HCG Excess:

    • TSH-Secreting Pituitary Adenoma

    • Gestational Trophoblastic Neoplasm

Low Radioiodine Uptake

 - Subacute Thyroiditis:

    • Granulomatous

    • Lymphocytic

    • Postpartum

    • Amiodarone

    • Radiation

 - Exogenous/Ectopic Hormone:

    • Excessive Thyroid Drug

    • Struma Ovarii



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