Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
• Artifact (redo CBC)
Autonomous:
• Essential thrombocytosis
• Polycythemia Vera
• Chronic Myelogenous Leukemia
• Primary Myelofibrosis
Infectious:
• Acute or Chronic
Inflammatory:
• IBD
• Rheumatic disorders
• Celiac disease
Tissue Damage:
• Post-op surgery
• Trauma
• Burns
Non malignant hematologic conditions:
• Rebound effect following treatment of ITP
• Rebound effect following EtOH induced thrombocytopenia
Other:
• Post-splenectomy or hyposplenic states
• Non-hematologic malignancy
• Iron deficiency anemia
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