Causes of Thrombocytopenia - Differential Diagnosis ...
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Causes of Thrombocytopenia - Differential Diagnosis Algorithm

 

Decreased Megakaryopoiesis

 • Aplastic Anemia

 • Toxic Damage (e.g. Chemotherapy)

 • Displacement (e.g. Leukemia, Tumour)

Ineffective Megakaryopoiesis

 • B12 Deficiency

 • Folate Deficiency

 • Folate Antagonist (methotrexate)

 • Drugs

Autoimmune

 • ITP

 • SLE

 • CLL

 • APLA

Alloimmune

 • anti-HLA antibodies 

Drugs

 • Quinidine

 • HIT

 • Others

Non-lmmune:

 • HELLP Syndrome

 • TTP/HUS

 • DIC

 • Vasculitis

 • Infection

 • Foreign Surface (e.g. Prosthetic Heart Valve)



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