Antimicrobial Regimens for Acute Bacterial Rhinosinusitis ...
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Antimicrobial Regimens for Acute Bacterial Rhinosinusitis in Adults

Initial empirical therapy: 

 • Amoxicillin-clavulanate (500 mg/125 mg PO tid, or 875 mg/125 mg PO bid)

 • Doxycycline (100 mg PO bid or 200 mg PO qd)

Beta-lactam allergy:

 • Doxycycline (100 mg PO bid or 200 mg PO qd)

 • Levofloxacin (500 mg PO qd)

 • Moxifloxacin (400 mg PO qd)

Risk for antibiotic resistance or failed initial therapy:

 • Amoxicillin-clavulanate (2000 mg/125 mg PO bid)

 • Levofloxacin (500 mg PO qd)

 • Moxifloxacin (400 mg PO qd)

Severe infection requiring hospitalization:

 • Ampicillin-sulbactam (1.5–3 g IV every 6 h)

 • Levofloxacin (500 mg PO or IV qd)

 • Moxifloxacin (400 mg PO or IV qd)

 • Ceftriaxone (1–2 g IV every 12–24 h)

 • Cefotaxime (2 g IV every 4–6 h)



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Contributed by

Dr. Gerald Diaz
@GeraldMD
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG:  https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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