Select Antiretroviral and Non–Rifamycin-based Antituberculosis ...

Select Antiretroviral and Non–Rifamycin-based Antituberculosis Drug Overlapping Toxicities and Potential Adverse Drug–Drug Interactions

 • Arrhythmias, QT interval prolongation - Fluoroquinolones, bedaquiline, delamanid, clofazimine

 • Hepatic cytochrome P450 enzyme system metabolism - Bedaquiline, delamanid

 • Nephrotoxicity - Aminoglycosides, capreomycin

 • Mental health changes (depression, psychosis, dizziness, etc.) - Cycloserine, isoniazid, ethionamide, fluoroquinolones

 • Peripheral neuropathy - Aminoglycosides, capreomycin, linezolid, isoniazid, ethionamide, cycloserine, fluoroquinolones

 • Hepatotoxicity - Isoniazid, pyrazinamide, ethionamide, p-aminosalicylic acid, clofazimine

 • Skin rash - All TB drugs, Note skin pigmentation with clofazimine use. Thioacetazone should be avoided in people with HIV, because of an elevated risk of a severe adverse skin reaction

 • Dysglycemia - Ethionamide, p-aminosalicylic acid, fluoroquinolones, linezolid

 • Myelosuppression/cytopenias - Linezolid

 • Lactic acidosis - Linezolid

#Antituberculosis #Drug #toxicities #adverseeffects #sideeffects #interactions #pharmacology
Contributed by

Dr. Gerald Diaz
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: | Twitter:
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