Myasthenia Gravis
Myasthenia gravis is an autoimmune disorder of the postsynaptic neuromuscular junction - associated with thymic tumors, paraneoplastic effects of SCC or hodgkin lymphoma. Autoimmune: thyroid, Sjogren syndrome, rheumatoid arthritis, SLE
Clinical picture - fluctuating degree/variable degree of weakness in:
1. Ocular- 50%. Ptosis, diplopia
2. Bulbar- 15%. Dysphagia, dysarthria, hypophonia, fatiguable chewing, loss of smile
3. Neck "dropping head syndrome"
3. Limb - proximal weakness, arms > legs
4. Respiratory muscles- "myasthenia crises" Respiratory insuffciency and life threatening
Diagnosis:
- Clinical Diagnosis
- Bedside: ice pack test/ Edrophonium test
- Cogan sign
- Peek sign
Electrophysiologic confirmation:
- Repetitive nerve stimulation
- Single fiber electromyography
Labs:
- AchR antibodies- first step in immunologic assay
- MuSK antibodies
- LRP4 antibodies
Rx:
- Symptomatic treatment: acetylcholinesterase inhibition
- Chronic immunosuppressive therapies: steroids and NSAIDS
- Immunomodulating treatments: IVIG and Therapeutic plasma exchange
- Surgical Treatment: Thymectomy
- Dr. Ravi Singh @rav7ks
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