Transfusion Restrictions - Leukoreduction, Irradiation ...
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Description

Transfusion Restrictions - Leukoreduction, Irradiation and Saline-Washing - Indications

Leukoreduction (LR): Filters leukocytes to 

   (1) ↓ HLA sensitization in chronically transfused pts / heme malignancies, bone marrow / kidney / heart / lung transplant candidates (not liver transplant) 

   (2) ↓ CMV risk & 

   (3) ↓ febrile non-hemolytic transfusion rxn (FNHTR)

Irradiation: 

 • Prevents proliferation of donor T lymphocytes from attacking host marrow (TA-GVHD in 1st degree directed donors);

 • Indications: heme malignancy & BMT to prevent GVHD; 

 • Not indications: solid tumor, solid organ transplant, HIV+

Saline-washing: 

 • Removes anti-IgA Ab & plasma proteins; 

 • Indications: (1) hx severe anaphylaxis, (2) IgA def & anaphylaxis



#Leukoreduction #Irradiation #SalineWashing #Indications #Transfusion #Restrictions #management #hematology
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MGH White Book Manual
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Account created for the MGH Internal Medicine Housestaff Manual "White Book" - https://stk10.github.io/MGH-Docs/WhiteBook-2019-2020.pdf
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