Essential Thrombocytosis (ET) - (↑Plt)- Diagnosis and ...

Essential Thrombocytosis (ET) - (↑Plt)- Diagnosis and Management :

 • Sx: Similar to PV, Bleeding. (2/2 acquired vWF disorder, consider if plt > 1 million) 

 • Dx: Major WHO criteria: PLT >450k. BM Bx shows enlarged megakaryocytes with hyperlobulated nuclei. Mutations: JAK2 50%, CALR 30%, MPL 5%. Minor WHO criteria: Other clonal markers

 • Tx: All: ASA 81 (unless vWF disorder). If age>60 or ↑risk thrombosis: hydroxyurea > interferon-α > anagrelide 

 • Ddx: Infection, inflammation, iron deficiency, splenectomy, neoplasm

#Essential #Thrombocytosis #thrombocythemia #ET #Diagnosis #Management #oncology #hematology
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