CAR T-Cell Therapy
Chimeric antigen receptor T cells (CAR T cells): type of autologous therapy; T lymphocytes collected from the patient, genetically modified via transfection with a gene encoding a chimeric antigen receptor (CAR) that directs the T-cells against a selected antigen on the patient’s tumor.
CARs: consist of an extracellular domain that targets and binds a tumor antigen (i.e. CD19 in B-cell NHL and ALL) attached to intracellular domains that signal for T-cell activation (see figure).
• Cytokine-release syndrome (CRS)
• CAR-T-cell-related encephalopathy syndrome (CRES)
• CAR-T-cell-related hemophagocytic lymphohistiocytosis (HLH)/MAS
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