Chemotherapy Toxicities - Immunomodulators

Aldesleukin, Denileukin

 • Indications: 

    - Aldesleukin: Melanoma, RCC;

    - Denileukin: CTCL

 • Toxicities: Capillary leak syndrome, sepsis (↓PMN chemotaxis), cardiopulmonary disease, CNS toxicity, hypersensitivity, renal insufficiency, autoimmune diseases, vision loss (denileukin)

Lena/poma/thalidomide

 • Indications: MM, MDS (lena) 

 • Toxicities: Teratogenicity, neutropenia/thrombocytopenia, DVT/PE, MI, stroke, rash, SJS (lena), liver toxic, peripheral neuropathy, ?2˚ malignancy

IFN-alpha 

 • Indications: Hairy cell leukemia, KS, CML 

 • Toxicities: Flu-like sx, ↑LFTs, fatigue, depression, HLD, anorexia, cytopenias

ATRA 

 • Indications: APL 

 • Toxicities: Differentiation syndrome, hemorrhage, ↑ICP, xerosis, DIC, teratogenicity

Arsenic 

 • Indications: APL 

 • Toxicities: Differentiation Syndrome, ↑QTc, confusion, N/V/D, respiratory sx

Azacytidine 

 • Indications: MDS 

 • Toxicities: BM↓, constipation, N/V, renal/liver tox

Decitabine 

 • Indications: AML, CML, MDS 

 • Toxicities: BM↓, constipation, N/V/D, hyperglycemia, MSK pain, respiratory sx



#Immunomodulators #chemotherapy #Toxicities #SideEffects #pharmacology #oncology