Description
Chemotherapy Toxicities - Immunomodulators
Aldesleukin, Denileukin
• Indications:
- Aldesleukin: Melanoma, RCC;
- Denileukin: CTCL
• Toxicities: Capillary leak syndrome, sepsis (↓PMN chemotaxis), cardiopulmonary disease, CNS toxicity, hypersensitivity, renal insufficiency, autoimmune diseases, vision loss (denileukin)
Lena/poma/thalidomide
• Indications: MM, MDS (lena)
• Toxicities: Teratogenicity, neutropenia/thrombocytopenia, DVT/PE, MI, stroke, rash, SJS (lena), liver toxic, peripheral neuropathy, ?2˚ malignancy
IFN-alpha
• Indications: Hairy cell leukemia, KS, CML
• Toxicities: Flu-like sx, ↑LFTs, fatigue, depression, HLD, anorexia, cytopenias
ATRA
• Indications: APL
• Toxicities: Differentiation syndrome, hemorrhage, ↑ICP, xerosis, DIC, teratogenicity
Arsenic
• Indications: APL
• Toxicities: Differentiation Syndrome, ↑QTc, confusion, N/V/D, respiratory sx
Azacytidine
• Indications: MDS
• Toxicities: BM↓, constipation, N/V, renal/liver tox
Decitabine
• Indications: AML, CML, MDS
• Toxicities: BM↓, constipation, N/V/D, hyperglycemia, MSK pain, respiratory sx
#Immunomodulators #chemotherapy #Toxicities #SideEffects #pharmacology #oncology