Description
Autoimmune Rheumatologic Medications:
Drug/Class, Indications and Common Toxicities
• Azathioprine (AZA; Imuran) - DM/PM, RA, SLE nephritis, vasculitis
• Cyclophosphamide (CYC; Cytoxan) - SLE (LN), vasculitis (most severe)
• Hydroxychloroquine (HCQ; Plaquenil) - RA, SLE, Sjogren’s
• Leflunomide (LFM; Arava) - PsA, RA
• Methotrexate (MTX; Rheumatrex, Trexall, Otrexup, Rasuvo) - RA (first line), PsA
• Mycophenolate Mofetil (MMF; CellCept) - AAV, DM/PM, PsA, Scleroderma, SLE
• Sulfasalazine (5-ASA; Azulfidine) - AS, IBD, JRA, psoriasis, RA
• Apremilast (Otezla); PDE4 inhibitor - PsA, severe psoriasis
• Tofacitinib (Xeljanz); JAK inhibitor - RA, AS, psoriasis
BIOLOGIC, non-TNF
• Abatacept (Orencia); CTLA-4 - PsA, RA
• Anakinra (Kineret); anti-IL-1R - AOSD/MAS, gout, Schnitzler syndrome
• Belimumab (Benlysta); anti-BAFF - SLE
• Canakinumab (Ilaris); anti-IL-1b - CAPS, CAD
• Rituximab (Rituxan); anti-CD20 - APLAS, GPA/MPA, IgG4-RD, Scl-ILD, (SLE)
• Tocilizumab (Actemra); anti-IL-6R - GCA, RA
• Secukinumab (Cosentyx); anti-IL17A - AS, PsA, psoriasis
• Ustekinumab (Stelara); anti-IL-12/23 - PsA, psoriasis
• IVIG - APLAS, DM/PM, IBM, IMNM, Kawasaki’s
BIOLOGIC, TNF inhibition
• Adalimumab (Humira); anti-TNF - AS, IBD, PsA, psoriasis, RA
• Infliximab (Remicade); anti-TNF - AS, IBD, PsA, psoriasis, RA
• Golimumab (Simponi); anti-TNF - AS, IBD, PsA, RA
• Certolizumab (Cimzia); anti-TNF - AS (axial), IBD, RA
• Etanercept (Enbrel); sol. TNF-R - AS, PsA, psoriasis, RA
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