Common Anti-Epileptic Drugs (AEDs) and Side Effects
Levetiracetam ...
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Common Anti-Epileptic Drugs (AEDs) and Side Effects

Levetiracetam (Keppra) - Psychiatric sx (irritability, anxiety, depression, sedation, psychosis).

Valproic acid (Depakote) - Teratogenic. Abnormal LFTs, weight gain, N/V, encephalopathy (↑ NH3), pancreatitis, thrombocytopenia. Good for mood disorders.

Phenytoin (Dilantin), Fosphenytoin - Teratogenic. Gingival hypertrophy, hair growth, rash, AMS, diplopia, ataxia, slurred speech, hypotension/arrythmia (if run faster than 50mg/min; Fosphenytoin is less cardiotoxic).

Lamotrigine (Lamictal) - Rash, SJS, nausea, somnolence, dizziness, ataxia. Good in mood disorders.

Topiramate (Topamax) - Weight loss, fatigue, teratogenic. Nephrolithiasis, cognitive, anxiety, anorexia, tremor

Lacosamide (Vimpat) - Headache, diplopia, dizziness, nausea, hypotension. Obtain EKG after load, and watch for PR prolongation.

Carbamazepine (Tegretol) - SIADH, N/V/D, rash, pruritis, fatigue, blurred vision, diplopia, lethargy. 



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