Common Anti-Epileptic Drugs (AEDs) and Side Effects
Levetiracetam (Keppra) - Psychiatric sx (irritability, anxiety, depression, sedation, psychosis).
Valproic acid (Depakote) - Teratogenic. Abnormal LFTs, weight gain, N/V, encephalopathy (↑ NH3), pancreatitis, thrombocytopenia. Good for mood disorders.
Phenytoin (Dilantin), Fosphenytoin - Teratogenic. Gingival hypertrophy, hair growth, rash, AMS, diplopia, ataxia, slurred speech, hypotension/arrythmia (if run faster than 50mg/min; Fosphenytoin is less cardiotoxic).
Lamotrigine (Lamictal) - Rash, SJS, nausea, somnolence, dizziness, ataxia. Good in mood disorders.
Topiramate (Topamax) - Weight loss, fatigue, teratogenic. Nephrolithiasis, cognitive, anxiety, anorexia, tremor
Lacosamide (Vimpat) - Headache, diplopia, dizziness, nausea, hypotension. Obtain EKG after load, and watch for PR prolongation.
Carbamazepine (Tegretol) - SIADH, N/V/D, rash, pruritis, fatigue, blurred vision, diplopia, lethargy.
#AntiEpileptic #Drugs #AEDs #pharmacology #table #neurology #comparison