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Opana ER is an extended-release formulation of oxymorphone, an opioid medicine used in certain pain-management situations. Its formulation allows the active ingredient to be released gradually, supporting longer-lasting effects compared with some immediate-release medicines. Oxymorphone works primarily through opioid receptors in the nervous system. Possible side effects include constipation, nausea, dizziness, drowsiness, and weakness. Opioids can also affect breathing, particularly when combined with alcohol or other medicines that cause sedation. Opana ER should not be altered, crushed, or otherwise manipulated unless a qualified healthcare professional specifically provides appropriate instructions, because changing an extended-release formulation can affect how the medicine enters the body. Safe storage and careful handling are essential.

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