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Codeine is a prescription opioid medication (opiate analgesic and antitussive). It is a naturally occurring alkaloid from the opium poppy, converted in the body (via CYP2D6 enzyme) to morphine for its main effects. It reduces pain perception and suppresses the cough reflex.
FDA-Approved Uses — In Which Cases It Is Used
Codeine is indicated for:

Relief of mild to moderately severe pain (often in combination with acetaminophen like Tylenol with Codeine, aspirin, or NSAIDs; single-ingredient codeine sulfate for pain).
Suppression of non-productive cough (in low-dose combination cough syrups like Robitussin AC or Phenergan with Codeine).
Occasionally for diarrhea (less common now, as loperamide or other agents preferred).

It is not a first-line treatment — used short-term when non-opioid options (e.g., ibuprofen, acetaminophen) are insufficient. Not recommended for children under 12 (FDA contraindication since 2017 due to respiratory depression/death risk from ultra-rapid metabolizers); restricted in ages 12–18; avoid in breastfeeding women.
Dosage (Typical Guidelines — Doctor Determines Exact)
Dosage varies by formulation, pain severity, tolerance, and patient factors (e.g., age, liver/kidney function). From reliable sources (e.g., MedlinePlus, StatPearls, FDA labels):

Pain (adults): 15–60 mg every 4–6 hours as needed (oral tablets/solution); max usually 360 mg/day.
Cough (adults, low-dose combos): 10–20 mg every 4–6 hours; max often 120 mg/day (e.g., 5 mL syrup every 4–6 hours for promethazine/codeine).
Take with food if stomach upset occurs; do not exceed prescribed dose.
Short-term use only; taper if prolonged to avoid withdrawal.

Common side effects: Drowsiness, constipation, nausea/vomiting, dizziness, dry mouth, sweating. Serious risks: Respiratory depression (slow/shallow breathing — potentially fatal, especially in children/elderly), overdose, addiction/dependence, serotonin syndrome (with certain meds), allergic reactions.