Algorithm for the Treatment of Membranous Lupus Nephritis
Sub-nephrotic-range ...
277
Description

Algorithm for the Treatment of Membranous Lupus Nephritis

Sub-nephrotic-range proteinuria (<3.5g/d, normal serum albumin) and Preserved kidney function

1. Hydroxychloroquine

2. Kidney protective therapy

3. Immunosuppression to treat non-renal SLE

4. Consider immunosuppression to treat class V LN if proteinuria > 1 g/d

Close monitoring is recommended: Evaluate for worsening disease, Evaluate for transition to proliferative from of LN

Nephrotic proteinuria and/or worsening kidney function

1. Hydroxychloroquine

2. Kidney protective therapy

3. Immunosuppressive therapy to treat class V LN

 • MMF 2-3 g/d ± corticosteroid to treat extra-renal SLE

 • Calcineurin inhibitor therapy (cyclosporine or tacrolimus) ± corticosteroids

 • Cyclophosphamide ± corticosteroids

 • Multi-target therapy (MMF plus CNI)

 • Azathioprine ± corticosteroids



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Contributed by

Dr. Gerald Diaz
@GeraldMD
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG:  https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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