Compelling and Possible Contraindications to Antihypertensive ...
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Compelling and Possible Contraindications to Antihypertensive Drugs

Diuretics (thiazides)

 - Gout

 - Metabolic syndrome, Glucose intolerance, Pregnancy, Hypercalcemia, Hypokalemia, Erectile dysfunction

Mineralocorticoid receptor antagonists (MRA)

 - Hyperkalemia, Serum creatinine >2.5 mg/dl„ in men, >2.0 mg/dL in women)

 - Situations associated with higher risk of hyperkalemia (ACEI, ARB, diabetes)

ACE inhibitors

 - Pregnancy, Angioneurotic edema, Hyperkalemia, Bilateral renal artery stenosis

 - Women with child-bearing potential

Angiotensin receptor blockers

 - Pregnancy, Hyperkalemia, Bilateral renal artery stenosis

 - Women with child-bearing potential

Ca2+ channel blockers (dihydropyridines)

 - Tachycardia/arrhythmia, Heart failure

Ca2+ channel blockers (verapamil, diltiazem)

 - AV block (grade 2-3), Severe LV dysfunction, Heart failure

 - Co-medication with CYP3A4- or Pgp-dependent drugs (e.g. statins, digoxin)

Beta Blockers

 - Asthma, AV block (grade 2-3)

 - Metabolic syndrome, Glucose intolerance, Athletes and physically active patients, Chronic obstructive lung disease, Psoriasis, Depression

Alpha Blockers

 - Heart failure

Central sympatholytic drugs

 - Depression, AV block (grade 2-3)

 - Erectile dysfunction, Xerostomia



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