NSAIDS and COX Selectivity



Relative selectivity of some commonly used NSAIDs. Data shown as the logarithm of their ratio of IC80 (drug concentration to achieve 80% inhibition of cyclooxygenase).



COX-1 Selectivity, More to Less:

 • Ketorolac, Aspirin, Flurbiprofen, Ketoprofen, Indomethacin, Naproxen, Tolmetin, Ibuprofen, Fenoprofen

COX-1 Selectivity, Less to More:

 • Piroxicam, Diclofenac, Celecoxib, Meloxicam, Etodolac

 

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