Causes of Hypocalcemia - Differential Diagnosis
Decreased ...
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Causes of Hypocalcemia - Differential Diagnosis

Decreased calcium absorption

 • Vitamin D deficiency

    - Decreased oral intake - Malnutrition

    - Decreased intestinal absorption - Intestinal bypass, gastrectomy

    - Decreased production of 25(OH)D3 - Liver failure

    - Decreased synthesis of 1,25(OH2)D3 - Renal failure, hyperphosphatemia

 • Malabsorption Syndromes

Increased calcium excretion/reduced bone resorption

 • Alcoholism - Hypomagnesemia causing inhibition of PTH secretion, PTH resistance to bone resorption

 • Hypoparathyroidism - Genetic, autoimmune, surgical, tumoral

 • Pseudohypoparathyroidism - Resistance to PTH action

 • Hypomagnesemia - Inhibition of PTH secretion, PTH resistance to bone resorption

 • Drugs

 • Miscellaneous

 • Sepsis

 • Acute pancreatitis - Fatty acids combine with [Ca2+] to form insoluble Ca2+ soaps and lead to a reduction of serum [Ca2+]

 • Massive transfusions

 • Rhabdomyolysis



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