Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis

 • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis, Osteomyelitis / Discitis, Infected hardware, Infected thrombosis, (e.g. Lemierre's syndrome), Malaria, Brucellosis, Q fever, EBV, CMV

 • Malignancy:

    - Hematologic malignancies: Lymphoma, Leukemia, Multiple myeloma

    - Solid tumors: Renal cell carcinoma, Pancreatic adenocarcinoma, Hepatocellular carcinoma

 • Non-infectious Inflammatory Diseases (e.g. autoimmune): Lupus, Rheumatoid arthritis, Vasculitis (Temporal arteritis is prob the most common vasculitis to cause FUO), Sarcoidosis, Adult onset Still's disease, Familial Mediterranean fever

 • Miscellaneous: Drug fever, Factitious fever, Hypothalamic dysfunction, Castleman disease, Kikuchi disease, Idiopathic



- Dr. Eric Strong @DrEricStrong



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