GLP-1 Receptor Agonists - Pharmacology Summary
Mechanisms ...

GLP-1 Receptor Agonists - Pharmacology Summary

Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1 = Glucagon-like peptide 1; normally produced by the gut)


 • Exenatide (Byetta) - Twice/day or weekly injection (ER version)

 • Liraglutide (Saxenda, Victoza) - Daily injection

 • Dulaglutide (Trulicity) - Weekly injection

 • Semaglutide - Weekly injection (Ozempic), or daily tablet (Rybelsus)

Major Advantages:

 • Weight loss (~1.5-2.5kg)

 • Liraglutide, dulaglutide, and semaglutide variety of adverse CV outcomes in high risk patients with T2D + atherosclerotic heart disease


 • Personal or family history of medullary thyroid cancer

 • Personal history of pancreatitis

Common Side Effects and Toxicities:

 • Gl side effects (e.g. diarrhea, nausea, worsen preexisting gastroparesis?)

 • Association with pancreatitis (though not definitively cause/effect)

 • May ↑ risk of medullary thyroid cancer

- Dr. Eric Strong @DrEricStrong - Strong Medicine

#GLP1 #Receptor #Agonists #Pharmacology #Summary #DM2 #diabetes #endocrinology
Contributed by

Dr. Gerald Diaz
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: | Twitter:
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