DPP-4 Inhibitors - Pharmacology Summary
Mechanisms ...
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Description

DPP-4 Inhibitors - Pharmacology Summary

Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1 and GIP.

Examples:

 • Sitagliptin (Januvia) - Once/day tablet

 • Saxagliptin (Onglyza) - Once/day tablet

 • Linagliptin (Tradjenta) - Once/day tablet

Major Advantages: None specific

Contraindications:

 • Recommended to avoid combination therapy with GLP-I receptor agonist

 • Personal history of pancreatitis

 • Saxagliptin is contraindicated in heart failure

Common Side Effects and Toxicities:

 • Joint pains, myalgias

 • Association with pancreatitis (though not definitively cause/effect)

 • Saxagliptin is associated with t risk of heart failure hospitalizations



- Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedicalLectures/featured



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Contributed by

Dr. Gerald Diaz
@GeraldMD
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG:  https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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