Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive ...
148
Description

Causes of Bone/Joint Pain in Sickle Cell Disease

Vaso-occlusive pain:

 • Mechanism: ischemic pain

 • Can present from infancy throughout life.

 • Generally affects long bones.

 • Repeat episodes predispose to other orthopedic complications.

Avascular necrosis:

 • Affects 10% of patients w SCD.

 • Most common sites: hip, shoulder.

 • XR, MRI to dx and stage.

 • PEx limited diagnostically. Early dz difficult to see on XR.

Osteomyelitis / Septic Arthritis:

 • Common d/t impaired splenic function -> think about encapsulated bugs.

 • Differentiate from vaso-occlusive pain w elevated CRP.

 • Hematogenous spread as source.



- BWH Medicine Chiefs @BrighamChiefs



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Contributed by

Dr. Gerald Diaz
@GeraldMD
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG:  https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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