Fever vs Hyperthermia
 • Regulated in the ...

Fever vs Hyperthermia


 • Regulated in the hypothalamic thermoregulatory center

 • "Set point" raised by prostaglandin E2

 • Triggered by pyrogens: Endotoxins, Toxins, Cytokines (IL-1, TNF-a1pha, IL-6, etc.)

 • Antipyretics block prostaglandin E2 production

 • Treatment: Use antipyretics to block prostaglandin E2 production and decrease the elevated hypothalamic set-point


 • Not regulated by hypothalamic set point

 • Body temperature rises uncontrollably

 • Can be rapidly fatal

 • Causes: Drugs: Ecstasy, atropine; Heat stroke; Malignant hyperthermia; Neuroleptic malignant syndrome; Serotonin syndrome

 • Treatment: 

   - Identify underlying cause

   - Antipyretics are of no use

   - Cool damp sponge bath (no submersion) to allow for evaporative heat loss

   - Cool fluids peripherally

   - Cooling blankets can cause harm as they lead to peripheral vasoconstriction, preventing heat loss from the skin

BWH Medicine Chiefs @BrighamChiefs

#Fever #Hyperthermia #comparison #diagnosis #management #treatment
Contributed by

Dr. Gerald Diaz
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG:  https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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