Hodgkin Lymphoma (HL) arises from germinal center or post-germinal center B cells. HL has a unique cellular composition, containing a minority of neoplastic cells (Reed-Sternberg cells and their variants) in an inflammatory background.
Reed-Sternberg cell is a characteristic feature of HL.
• Lymphadenopathy - painless, firm cervical or supraclavicular node, Anterior mediastinal mass/ adenopathy
• Cough, Dyspnea, fever, Night sweats, Weight loss, Anaemia, Pruritis, Erythema nodosum, Immune hemolytic anemia, Pain in LN on alcohol ingestion, B symptoms in 1/3 of pts
• Classical HL - (90-95% of cases). The tumor cells in this group are derived from germinal center B cells, but typically fail to express many of the genes and gene products that define normal germinal center B cells. Classical HL is further divided into the following subtypes:
• Nodular sclerosis classical HL (NSHL) - (most common)
• Mixed cellularity classical HL (MCHL)
• Lymphocyte rich classical HL (LRHL)
• Lymphocyte depleted classical HL (LDHL)
• Nodular lymphocyte predominant HL - The tumor cells in this subtype retain the immunophenotypic features of germinal center B cells.
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