HHV8/KSHV-reIated diseases: From Cellular Proliferation ...

HHV8/KSHV-reIated diseases: From Cellular Proliferation to Hyperinflammation

Kaposi sarcoma (KS):

 • Target organs: Ubiquitous (cutaneous and mucosal predominance)

 • Clinical features: Blue-violet macules or nodules (+/- according to visceral involvement)

 • Histology: LANA+ fusiform cells (*) from endothelium

 • Association HIV/EBV: Yes/No

 • Clonality: Polyclonal (except nodular forms)

 • Light chain: -

HHV8+ Multicentric Castleman Disease (MCD):

 • Target organs: Lymph nodes and spleen

 • Clinical features: Fever, adenopathies (ADP), splenomegaly, effusion, hemophagocytosis

 • Histology: LANA+ plasmablasts from pre-GC B cells

 • Association HIV/EBV: Yes/Rare

 • Clonality: Polyclonal

 • Light chain: Constant λ Monotype

Primary effusion lymphoma (PEL):

 • Target organs: Pleural, pericardial, peritoneal cavities

 • Clinical features: Effusion, B symptoms

 • Histology: LANA+ immunoblastic/anaplasic cells from differentiated B cells

 • Association HIV/EBV: Yes / Yes

 • Clonality: Monoclonal

 • Light chain: Monotype

By Dr. Gregoire Martin de Fremont

#HHV8 #diseases #comparison #diagnosis #kshv #kaposi #humanherpesvirus 
Contributed by

Dr. Gerald Diaz
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG:  https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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